Expression of Interest

Contact Person/Scientist in Charge

  • Name and surname: Marcos Lopez Hoyos
  • Email:

IDIVAL (Biomedical Research Institute)

Department / Institute / Centre

  • Name: Marqués de Valdecilla Biomedical Research Institution (IDIVAL)
  • Address: avda cardemal herrera oria santander
  • Province: Cantabria

Research Area

  • Life Sciences (LIF)

Brief description of the institution:

Valdecilla Research Institute (IDIVAL; is the main institution dedicated to biomedical research in the autonomous region of Cantabria. It is patronized by both the University of Cantabria (UC) and the Cantabrian Health Service (Servicio Cántabro de Salud, SCS), which is the public organism in charge of providing medical assistance to the vast majority of the population.
The core of IDIVAL activity is the University Hospital Marqués de Valdecilla, a tertiary care facility with over 700 beds and all major medical and surgical specialities ( Nevertheless, IDIVAL included both clinically-oriented groups, as well as groups focused on more basic research, but the overall goal of the institution is to foster high quality patient and disease-oriented translational research. The quality of IDIVAL research led the institution to be recognized as an accredited Health Research Institute (“Instituto de Investigación Sanitaria”) by the Spanish Government.
Although UC and IDIVAL are relatively small in comparison with other institutions, the close collaboration between the University and the Health System, and specifically the University Hospital, is allowing IDIVAL to foster basic-clinical collaborations and a fast-growing and excellent research activity, specifically oriented to generate new knowledge helping to solve the medical problems of the population. That is the reason why IDIVAL activity focuses in prevalent disorders, such as cancer, neurodegenerative disorders, cardiovascular...

Brief description of the Centre/Research Group (including URL if applicable):

The transplantation and autoimmunity group is focused on these research lines:


  • 1. Non-invasive blood and urine biomarkers of clinical events related to solid organ transplantation
  • 2. Immunoregulation in kidney and lung transplantation.
  • 3. Intensive treatment of donors to increase the number of grafts suitable for transplantation. 


  • 1. Inflammatory diseases associated with aging 
  • 2. Antiphospholipid syndrome.
  • 3. Biomarkers.

If you need more information, you can visit our web page 

Project description:

Our core track of research is to identify immunological biomarkers that help in the monitoring of solid organ transplantation with special focus in kidney and lung transplantation. Our subject of study comes from the great progress in cellular and molecular immunology, coupled with an increasing interest on translational research and personalized medicine.

In general, our goal is to search a panel of biomarkers helping to manage the immunosuppression in solid organ transplant recipients coming from immunological tolerance models to humans (in close relationship with the basic models from the Cantabria University and CSIC: Prof. Jesús Merino and Ramón Merino).

We assess the markers in peripheral blood because we consider this is the most minimally invasive and practical source for clinical use. Thus, the project can be situated in the domain of transplantation and immunological tolerance biomarkers. The biomarkers can be grouped in one or several panels according to the clinical focus: humoral rejection, acute or chronic, immunosuppression minimization, etc.

Our approach is to serially measure allo-antibodies (anti-HLA- and others) and auto-antibodies, inflammatory proteins, peripheral blood immune regulatory cells and immune allo-reactivity, and peripheral blood gene expression patterns.

We are a small centre (almost 600000 attending population) with a very close relationship between clinical and basic researchers what helps to perform translation research.

In addition, our group also has a research line in autoimmune diseases what facilitates the interchange between allo and autoimmunity findings which are closely related. Again, the interplay between clinicians and us is very close what facilitates the output.


We are looking for a highly motivated person with a MD or PhD degree, willing to spend 1-3 years in our lab.  

Individuals who are interested should submit a detailed CV, a brief statement of interests and skills, the names of two references, and a short description of their training and future research goals to  Dr. Marcos Lopez Hoyos ( Please, include in the subject “Marie Curie application).

I want to contact the Institution

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